Health Condition 1: M05- Rheumatoid arthritis with rheumatoid factor Health Condition 2: M06- Other rheumatoid arthritis
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Intervention3: Nil: Nil
Control Intervention1: Nil: Nil
Sponsors
Dr Shreya Menon
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with Rheumatoid Arthritis (RA) based on the 2010 ACR/EULAR classification criteria, either as inpatients or outpatients, will be recruited for the study. 2. Age greater than or equal to 18 years. 3. Either treatment naive or patients who have not been adequately treated with csDMARDs (conventional synthetic Disease Modifying Antirheumatic Drugs) and tsDMARDs (targeted synthetic Disease Modifying Antirheumatic Drugs), as well as those who have discontinued treatment or have poor adherence. 4. Willing to participate and provide informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who have received adequate dose of csDMARDs and tsDMARDs in the last 1 month. 2. Patients on steroids (10 mg/day of prednisolone or equivalent) in the past 4 weeks before enrollment. 3. Patients with iron deficiency anemia or thrombocytopenia 4. Patients with active infections such as tuberculosis or chronic viral hepatitis 5. Patients with concurrent autoimmune or inflammatory diseases such as lupus, psoriatic arthritis or inflammatory bowel disease. 6. Patients with a history of malignancy. 7. Pregnant or breast feeding women 8. Patients with severe renal or hepatic impairment (eGFR less than 30ml per minute per 1.73 metre square or liver enzymes greater than 3 times the upper limit of normal)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the Systemic Immune-Inflammation Index (SII) as a biomarker for disease activity and treatment response in newly diagnosed Rheumatoid Arthritis (RA) patients over a 12 month periodTimepoint: At 3 months, 6 months and 12 months | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the correlation between SII and established disease activity indices - Clinical Disease Activity Index (CDAI) and Simplified Disease Activity Index (SDAI), in newly diagnosed RA patientsTimepoint: At 3 months, 6 months and 12 months;To determine the ability of SII to predict changes in disease activity following initiation of therapy over a 12 month follow up.Timepoint: At 3 months, 6 months and 12 months | — |
Countries
India
Contacts
Public ContactDr Chandrashekar UK
Kasturba Medical College, Manipal
Outcome results
None listed