Health Condition 1: N859- Noninflammatory disorder of uterus, unspecified
Conditions
Interventions
Intervention1: Duloxetine: Duloxetine 60 mg 2 hour before surgery
Intervention2: Pregabalin: Pregabalin 150 mg 2 hour before surgery
Control Intervention1: Placebo capsule: Placebo capsule 2 hour befo
Sponsors
Apollo Hospitals Bilaspur
Eligibility
Inclusion criteria
Inclusion criteria: 1. ASA grade I and II 2. Scheduled for laparoscopic gynecological surgery under general anesthesia
Exclusion criteria
Exclusion criteria: 1. Known allergy to study drugs 2. History of PONV 3. Use of antiemetic drug within 24 hour of surgery 4. Morbid obesity (BMI.40) 5. Patient with history of hepatic, renal and cardiovascular dysfunction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fentanyl requirements Timepoint: Within 24 hours after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score at rest and on movement, adverse effects of study drugs (headache, nausea, vomiting, dry mouth, urinary retention, ileus, urticaria, hypotension, bradycardia, respiratory depression, itching), sedation score and patient satisfaction score. Timepoint: Within 24 hours after surgery surgery | — |
Countries
India
Contacts
Public ContactDr Vinit Kumar Srivastava
Apollo Hospitals Bilaspur
Outcome results
None listed