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Role of KIEL-67, CYCLIN D1 and P53 in early diagnosis and prognosis of oral cancers.

Role of KIEL-67 (KI-67), CYCLIN D1, and Tumor Protein (P53) in early diagnosis and in the prognosis of oral squamous cell carcinoma. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/06/088485
Enrollment
55
Registered
2025-06-10
Start date
Unknown
Completion date
Unknown
Last updated
2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C00-C14- Malignant neoplasms of lip, oral cavity and pharynx

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil Intervention4: Nil: Nil Intervention5: Nil: Nil

Sponsors

Datta Meghe Institute of Higher Education and Research (DMIHER)
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Confirmed cases of oral squamous cell carcinoma in resected specimens. 2.Confirmed cases of oral epithelial dysplasia/ other pre-malignant conditions. 3.Biopsy Samples with sufficient tissue for analysis.

Exclusion criteria

Exclusion criteria: 1.All Benign lesions. 2.Patients presented with recurrence of oral squamous cell carcinoma. 3.Patients who have taken previous chemotherapy or radiotherapy. 4.Biopsy specimens in which tissue is found to be inadequate for further processing for Immunohistochemistry. 5.Tissue blocks from which proper antigen retrieval could not be done adequately. 6.Patients who refused to give consent.

Design outcomes

Primary

MeasureTime frame
To conclude from Ki-67, Cyclin D1 and P53 immunohistochemistry for detecting their expression and to correlate with different histopathological grades of oral squamous cell carcinoma.Timepoint: 2 years—

Secondary

MeasureTime frame
NILTimepoint: NIL—

Countries

India

Contacts

Public ContactDr Khushi Soni

Datta Meghe Institute of Higher Education and Research (DMIHER)

keshaohiwale5@gmail.com09823749905

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026