An interventional study to compare efficacy between low flow rate and high flow rate of high flow nasal cannula in intensive care unit

Comparative efficacy of different flow settings of High Flow Nasal Cannula (HFNC) in ICU: An interventional pilot study - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/088436

Enrollment

Registered

2025-06-09

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J00-J99- Diseases of the respiratory system

Interventions

Intervention1: Comparison between efficacy of different flow settings of high flow nasal cannula in Intensive Care Unit: Randomised outcome assessor blinded, parellel group trial Duration 1 year Contr

Eligibility

Inclusion criteria

Inclusion criteria: All ICU patients of 18 to 60 years of age Any gender Respiratory rate more than 25 breaths/min Moderate to severe acidosis (pH 7.25 to 7.30) PaCO2 45 to 60 mmHg PaO2/FiO2 more than 100

Exclusion criteria

Exclusion criteria: Intubation requirement before recruitment for the study Hypercarbic respiratory insufficiency (PaCO2 more than 60 mmHg and PaO2 by FiO2 less than or equal to 100) Hemodynamic compromise Cardiac arrest Septic shock Patient not able to protect airway (GCS 3 by 15) Impaired mental status Extubated patients Severe acidosis (pH less than 7.2) Morbidly obese

Design outcomes

Primary

Measure	Time frame
To compare PaO2 by FiO2 ratio between different flow settings of high flow nasal cannulaTimepoint: Every 4 hours till weaning from High flow nasal cannula	—

Secondary

Measure	Time frame
Observe any requirement of NIV despite HFNC Number of intubation free days after HFNC initiation Successful weaning from HFNC or Mechanical ventilation Length of ICU stay and in ICU mortalityTimepoint: Every 24 hours till ICU stay	—

Countries

India

Contacts

Public ContactDr Soniya Bhatta

All India Institute of Medical Sciences, Rishikesh

Drankit80@gmail.com9761966555

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026