Evaluation of the Effects of Injectable Platelet-Rich Fibrin (PRF) and Its Combination with Low-Intensity Laser Therapy on the Speed of Canine Tooth Movement During Braces Treatment: A Randomized Controlled Trial.

Evaluation of effects of Injectable - Platelet Rich Fibrin and combination of Injectable -Platelet Rich Fibrin & Low Intensity Laser Therapy on the rate of canine retraction - A Randomized Controlled Trial. - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/088422

Enrollment

Registered

2025-06-06

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K089- Disorder of teeth and supporting structures, unspecified Health Condition 2: K089- Disorder of teeth and supporting structures, unspecified

Interventions

Intervention1: Canine Retraction using I- PRF and combination of I-PRF & LILT: After explaining the study to the patient, an informed consent will be taken from the patient before the start of the s

Eligibility

Inclusion criteria

Inclusion criteria: Patients of either sex with age group of 15-25 years. Angles class I or class II Division 1 malocclusion with Bimaxillary protrusion

Exclusion criteria

Exclusion criteria: Patients with previous history of orthodontic treatment Patient with canine having dilacerated roots. Patients with impacted canine. Patients with sign of gingival or periodontal disease. Patients with metabolic disorders that leads to bone pathologies.

Design outcomes

Primary

Measure	Time frame
To evaluate effects of Injectable Platelet Rich Fibrin and combination of Injectable Platelet Rich Fibrin and Low Intensity Laser Therapy on the rate of canine retractionTimepoint: T0: at the start of canine retraction. T1: at 1 st month after the start of canine retraction. T2: at 2 nd month after the start of canine retraction. T3: at 3 rd month after the start of canine retraction. T4: at the end of canine retraction.	—

Measure

Time frame

To evaluate effects of Injectable Platelet Rich Fibrin and combination of Injectable Platelet Rich Fibrin and Low Intensity Laser Therapy on the rate of canine retractionTimepoint: T0: at the start of canine retraction. T1: at 1 st month after the start of canine retraction. T2: at 2 nd month after the start of canine retraction. T3: at 3 rd month after the start of canine retraction. T4: at the end of canine retraction.

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Secondary

Measure	Time frame
To compare effects of Injectable Platelet Rich Fibrin & combination of Injectable Platelet Rich Fibrin & Low Intensity Laser Therapy on the rate of canine retractionTimepoint: T0: at the start of canine retraction. T1: at 1 st month after the start of canine retraction. T2: at 2 nd month after the start of canine retraction. T3: at 3 rd month after the start of canine retraction. T4: at the end of canine retraction.	—

Measure

Time frame

To compare effects of Injectable Platelet Rich Fibrin & combination of Injectable Platelet Rich Fibrin & Low Intensity Laser Therapy on the rate of canine retractionTimepoint: T0: at the start of canine retraction. T1: at 1 st month after the start of canine retraction. T2: at 2 nd month after the start of canine retraction. T3: at 3 rd month after the start of canine retraction. T4: at the end of canine retraction.

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Countries

India

Contacts

Public ContactDr Jyoti Manchanda

Government dental college and hospital ,Nagpur

drjyotimadaan@yahoo.com9423188175

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026