Research on Taurine and L-Carnitine supplements for relief of muscle cramps in patients with liver cirrhosis

A double-blind Randomized control trial to study the efficacy of combination of Taurine and L-Carnitine in alleviating muscle cramps in patients with liver cirrhosis.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/088418

Enrollment

Registered

2025-06-06

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K745- Biliary cirrhosis, unspecified Health Condition 2: K746- Other and unspecified cirrhosis ofliver Health Condition 3: K743- Primary biliary cirrhosis Health Condition 4: K744- Secondary biliary cirrhosis

Interventions

Intervention1: Taurine and L-Carnitine: Each sachet contains 3g Taurine and 1.465 g L-Carnitine Tartrate equivalent to 1g L-Carnitine Control Intervention1: Placebo: Each 535mg Placebo contains Mannit

Eligibility

Inclusion criteria

Inclusion criteria: Cirrhotic patients with muscle cramps frequency more than or equal to 3 times a week at rest or during sleep. Willing to provide informed consent and comply with study procedures.

Exclusion criteria

Exclusion criteria: Patients with known allergies to taurine or L-carnitine. No alcohol or IV drug use for the last 3 months. Blood glucose level more than 270mg/dl at the time of enrolment. Patients currently taking muscle relaxants or other supplements that might interfere with the study results. Pregnant or breastfeeding women. Patients with CKD. Patients with uncontrolled hepatic encephalopathy History of Peripheral neuropathy, Thyroid disease, Pulmonary hypertension, Cardiac disease

Design outcomes

Primary

Measure	Time frame
The objective of this study is to evaluate the efficacy of L-Carnitine and Taurine supplementation in reducing the frequency, severity, and duration of muscle cramps in patients with liver cirrhosis.Timepoint: Each patient from each of the 3 groups shall be followed up a total of 3 times: At 1st month: Via video consultation At 2nd month: Via video consultation At 3rd month: By physical consultation in OPD	—

Measure

Time frame

The objective of this study is to evaluate the efficacy of L-Carnitine and Taurine supplementation in reducing the frequency, severity, and duration of muscle cramps in patients with liver cirrhosis.Timepoint: Each patient from each of the 3 groups shall be followed up a total of 3 times: At 1st month: Via video consultation At 2nd month: Via video consultation At 3rd month: By physical consultation in OPD

—

Secondary

Measure	Time frame
nilTimepoint: nil	—

Countries

India

Contacts

Public ContactSukhada Thorat

Jaslok Hospital and Research Centre

aabhanagral@gmail.com9820156834

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026