Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Intrathecal morphine: Based on Dixons up and down methodology different doses of preservative-free intrathecal morphine along with 1 ml of 0.5% bupivacaine (heavy) will be administered
Sponsors
All India Institute of Medical Science
Eligibility
Inclusion criteria
Inclusion criteria: Adult ASA physical status I or II patients undergoing robotic prostate surgery.
Exclusion criteria
Exclusion criteria: a)Patients refusal to participate in the study b)BMI more than 30 and less than 18 c)Contraindications to neuraxial anaesthesia d)Allergy to bupivacaine or morphine e)High probability of moderate- severe OSA (STOP BANG more than 4) f)Poorly controlled COPD g)Severe LV systolic dysfunction h)CNS disease i)CKD stage 4 and 5 j)Unable to communicate effectively
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the median effective dose (ED50) of intrathecal morphine that provides adequate post-operative analgesiaTimepoint: Upto 24 hours from the end of surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the quality of post-operative recovery using Quality of Recovery (QoR-15) score Timepoint: After 24 hours from the end of surgery.;To find out the incidence of adverse effects of intrathecal morphineTimepoint: Upto 24 hours from the end of surgery | — |
Countries
India
Contacts
Public ContactKeerthana G
All India Institute of Medical Science
Outcome results
None listed