A study to see effect of High-Definition Transcranial Direct Current Stimulation compared to sham stimulation in reducing urge for alcohol in patient suffering from Alcohol Dependence Syndrome.

Effect of Adjunctive High-Definition Transcranial Direct Current Stimulation in reducing craving and relapse prevention in patients with Alcohol Dependence Syndrome - A Double Blinded Randomized Sham-Controlled Study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/088349

Enrollment

Registered

2025-06-06

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F102- Alcohol dependence

Interventions

Intervention1: High-Definition Transcranial Direct Current Stimulation [HD-tDCS]: ACTIVE HD-tDCS group: Will receive 10 sessions (2 per day) over 5 days. 2mA current and for 20 minutes in each sessio

0.2mA current and for 20 minutes in each session that is spaced over at least 4 hours. The anode will be placed over the left DLPFC, which is located at F3 based on the 10/20 electroencephalogram syst

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients diagnosed with Alcohol Dependence Syndrome as per ICD-10 DCR 2. Absent, minimal, mild to moderate withdrawal (as per CIWA-Ar score less than 10) and patient becoming clinically stable after admission. 3. Age between 18 -50 years 4. Any gender

Exclusion criteria

Exclusion criteria: 1. Patients with comorbid Dependence Syndrome of other substances (excluding nicotine and caffeine) 2. Patients currently in state of Alcohol related complicated Withdrawal (delirium tremens, withdrawal seizure) 3. Patients with a diagnosis of any other comorbid psychiatric disorder 4. Patients with alcohol or other substance related psychotic disorder 5. Patients with metal in cranium, pacemaker 6. Patients with history of epilepsy and Cerebrovascular Accident (CVA). 7. Patient with Pregnancy 8. History of serious adverse effect after Cranial Electric Stimulation

Design outcomes

Primary

Measure	Time frame
Craving for alcohol (measured using OCDS, ACQ-SF-R and VAS)Timepoint: 1. Baseline: Just before the delivery of first session (Day 0) 2. After completion of 10 sessions of HD tDCS. 3. Follow-up: After 4 weeks from the day of last session	—

Secondary

Measure	Time frame
Time to relapseTimepoint: (timeline: till four weeks from first session of tDCS)	—

Countries

India

Contacts

Public ContactDr Lokesh Kumar Singh

All India Institute of Medical Sciences Raipur

singhlokesh123@gmail.com8103624062

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026