Health Condition 1: K318- Other specified diseases of stomach and duodenum
Conditions
Interventions
Intervention1: Remifentanil: Remifentanil will be used for perioperative analgesia.
Induction Dose: 1mcg/Kg intravenously over 30-60 seconds.
Maintenance Dose: 0.1-0.3 mcg/Kg/minute intravenous infusi
Sponsors
AIIMS Bhopal
Eligibility
Inclusion criteria
Inclusion criteria: patient aged 18-65 years, undergoing emergency laparotomy for gastrointestinal perforation under general anaesthesia
Exclusion criteria
Exclusion criteria: Patients with polytrauma requiring multiple procedures, uncontrolled hypertension, hypersensitivity to opioids, chronic use of opioid, severe cardiovascular disease, adrenal disease, endocrine or metabolic disease, hormonal or vasoactive drug history, and on inotropic support.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma epinephrine, nor-epinephrine, cortisol and blood glucose levelsTimepoint: Before induction (T0), 5 minutes post intubation (T1), at incision (T2), 1 hour after incision (T3), and at the time of skin closure (T4). | — |
Secondary
| Measure | Time frame |
|---|---|
| Lymphocyte countsTimepoint: before induction (T0), at incision (T2), 1 hour after incision (T3), and at the time of skin closure (T4).;Mean arterial pressure (MAP), heart rate (HR), and perfusion index (PI)Timepoint: Before induction (T0), 5 minutes post intubation (T1), at incision (T2), 1 hour after incision (T3), and at the time of skin closure (T4). | — |
Countries
India
Contacts
Public ContactSAURABH TRIVEDI
saurabh.tem@aiimsbhopal.edu.in
Outcome results
None listed