Health Condition 1: L80- Vitiligo
Conditions
Interventions
Intervention1: ORAL TOFACITINIB: orally
6 months
5mg once a day(weight less than 20 kg)
5mg twice a day(weight more than 20 kg)
Intervention2: Oral azathioprine: 6 months
2 mg/kg per day orally
Contro
Sponsors
PGIMER Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: Arm1-Oral minipulse dexamethasone 2.5 mg on two days a week orally for 6 months Arm 2- Azathioprine 2mg/kg/day orally once a day for 6 months Arm3- Tofacitinib 5 mg once daily if weight 20 kg for 6 months
Exclusion criteria
Exclusion criteria: Age more than 18 years. Age less than 6 years Weight less than 20 kg (for tofacitinib) Leucoderma secondary to other causes Patients with severe hepatic, renal or other systemic disorder Pre-existing malignancy History of tuberculosis in past Patients with known hypersensitivity to the drug
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess stabilisation of disease activityTimepoint: To assess stabilisation of disease activity at 4 weeks, 8 weeks, 12 weeks, 16 weeks, 20 weeks, 24 weeks and 36 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| assess repigmentation in addition that is the proportion of patients achieving 50 % reduction in VES score from baseline.Timepoint: at 6 months | — |
Countries
India
Contacts
Public ContactM Sendhil Kumaran
PGIMER Chandigarh
Outcome results
None listed