Health Condition 1: E168- Other specified disorders of pancreatic internal secretion
Conditions
Interventions
Intervention1: Nil: Nil
Sponsors
Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry
Eligibility
Inclusion criteria
Inclusion criteria: All adult patients undergoing surgery for chronic pancreatitis Adult healthy volunteering participants
Exclusion criteria
Exclusion criteria: Patients not consenting for study Pregnancy and post-partum state Patients on steroids Patients with endocrine disorders like Cushing s syndrome, acromegaly Chronic kidney disease, chronic liver disease Patients who will not be able to drink 360 ml mixed meal diet
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To correlate the glycemic response with plasma insulin and glucagon before and after surgery for chronic pancreatitis. Timepoint: Before surgery, 3 months after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| To correlate the Morphometric changes in islet cell quantity on histopathology with the plasma insulin, glucagon secretion and its sensitivity indicesTimepoint: Before surgery, 3 months after surgery;1. To correlate the plasma GLP-1 level with blood glucose, plasma insulin and glucagon secretion before and after surgery for chronic pancreatitisTimepoint: Before surgery, 3 months after surgery;To correlate the plasma GIP level with blood glucose, plasma insulin and glucagon secretion before and after surgery for chronic pancreatitisTimepoint: Before surgery, 3 months after surgery | — |
Countries
India
Contacts
Public ContactDr Preethee U
Jawaharlal Institute of Postgraduate Medical Education and Research
Outcome results
None listed