A prospective randomised double blinded comparative study to compare the efficacy of intravenous ketamine versus intravenous granisetron pretreatment for amelioration of propofol injection pain

A prospective randomised double blinded comparative study to compare the efficacy of intravenous ketamine versus intravenous granisetron pretreatment for amelioration of propofol injection pain - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/088244

Enrollment

100

Registered

2025-06-04

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Group K: IV Ketamine 0.2mg/kg as pretreatment Control Intervention1: Group G: IV Granisetron 2mg as pretreatment

Eligibility

Inclusion criteria

Inclusion criteria: Adult patient of both sex aged between 20-60 years undergoing elective surgeries under general anaesthesia. Subjects belonging to physical status ASa 1 and 2

Exclusion criteria

Exclusion criteria: All ASA 3 and 4 Subjects posted for emergency procedures Pregnant patients Patients with known comorbidities Patients with nasogastric tube and patients having problem with communication Patients with difficult airway Patienrs in whom forearm veins are not accesible

Design outcomes

Primary

Measure	Time frame
To assess the incidence of moderate to severe pain after IV ketamine before propofol To assess the incidence of moderate to severe pain after IV granisetron before propofol to compare the efficacy of bothTimepoint: Soon after induction with propofol	—

Secondary

Measure	Time frame
To observe & compare SBP,MAP,HR,SPO2 between two groups intraoperatively to observe the incidence of adverse effects of ketamine & granisetronTimepoint: 0 & 1 minutes	—

Countries

India

Contacts

Public ContactVijayalakshmi B C

Mysore medical college

vijayanagaraj@yahoo.co.in9886239622

Outcome results