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Effectiveness of different community wide TB screening approaches in reducing the burden of TB in urban areas

A pragmatic cluster randomized control trial for assessing the effectiveness of two annual rounds of two different community-wide TB screening approaches in reducing TB prevalence in selected municipalities implementing the Swasthya Nagaram Initiative in Hyderabad, India - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/06/088178
Enrollment
225000
Registered
2025-06-03
Start date
Unknown
Completion date
Unknown
Last updated
2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Community-wide screening with chest X-ray: The chest X-ray will be offered to all eligible clients in this study arm regardless of the symptoms. Clients with symptoms suggestive of TB o

Sponsors

Gates Foundation
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adults residing for at least one month in the wards randomized to any of the three study arms.

Exclusion criteria

Exclusion criteria: Adults not willing to give consent, people with TB on Anti TB Treatment, pregnant women, and children less than 18 years of age, and severely ill or bedridden will be excluded from the study

Design outcomes

Primary

MeasureTime frame
Prevalence of bacteriologically confirmed pulmonary TB in Arm 1 and Arm 2 compare with Arm 3Timepoint: In third year of the project

Secondary

MeasureTime frame
Coverage of the screening algorithm and facilitators, barriers, and adaptations made to improve the uptake of screening in Arm-1 and Arm-2Timepoint: In third year of the project;Cost-effectiveness of Arm-1 and Arm-2 for preventing one additional TB case compared to Arm-3Timepoint: In third year of the project

Countries

India

Contacts

Public ContactDr Jyoti Jaju

International Union Against Tuberculosis and Lung Disease, India

Jyoti.Jaju@theunion.org9849904722

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026