This study aims at reducing bleeding and offer better view while operating by comparing two different techniques to lower pressure in great veins in patients undergoing liver surgeries- Glyceryl trinitrate infusion versus head end up position

Glyceryl trinitrate infusion versus reverse Trendelenburg position for controlled low central venous pressure in patients undergoing hepatectomy: a randomized controlled trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/088173

Enrollment

Registered

2025-06-03

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

Intervention1: glyceryl trinitrate versus reverse Trendelenburg position: To compare glyceryl trinitrate infusion versus reverse Trendelenburg position for achieving controlled low central venous pre

Eligibility

Inclusion criteria

Inclusion criteria: age group 18-70, all open resections- As low CVP being our primary outcome, we target low CVP for all resections irrespective of the segments involved.

Exclusion criteria

Exclusion criteria: liver resection involving other organs, patients with pulmonary hypertension, valvular heart disease, known allergy to glyceryl trinitrate.

Design outcomes

Primary

Measure	Time frame
Reduction in central venous pressure less than 5mmhg and percentage of reduction from baseline with reverse Trendelenburg position versus glyceryl trinitrate infusionTimepoint: before, during and after liver resection	—

Secondary

Measure	Time frame
Blood loss Lactate levels Pulse pressure variation & other hemodynamic parameters Requirement of blood transfusion Requirement of vasopressors Duration of ICU stayTimepoint: every 15 minutes till the end of liver resection & at end of surgery & at discharge	—

Countries

India

Contacts

Public ContactSubhavarshini M

Christian medical college, vellore

cmcrahulpillai@gmail.com9894460758

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026