Health Condition 1: O141- Severe pre-eclampsia
Conditions
Interventions
Intervention1: Nil: Nil
Sponsors
ALL INDIA INSTITUTE OF MEDICAL SCIENCES
Eligibility
Inclusion criteria
Inclusion criteria: 1. Pregnant women between 11 14 weeks of gestation 2. Singleton pregnancies with confirmed dating 3. Willing and able to provide informed consent 4. Planning to continue antenatal care and delivery at the study site
Exclusion criteria
Exclusion criteria: 1. Twin Pregnancies 2. Other high risk pregnancies like Diabetes Mellitus, Rh immunized pregnancies, SLE etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of PE-specific methylation signature in plasma-based cffDNA (circulating cell-free fetal DNA) fractionsTimepoint: comparing the maternal and fetal cell free DNA using different methods. the sample will be tested in between 11-14 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Compare predictive performance against standard multiparametric algorithms 2. Determine the feasibility of clinical implementation as a non-invasive screening tool.Timepoint: 1. Performance comparison will be done after pregnancy outcomes are known (retrospectively comparing first-trimester data with final diagnoses) between 11-14 weeks 2. Evaluation will occur throughout the study duration, focusing on sample processing, test performance, & ease of implementation. | — |
Countries
India
Contacts
Public ContactDr K Aparna Sharma
All India Institute of Medical Sciences, Delhi
Outcome results
None listed