Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Sugammadex: 2 mg/kg given as divided dose of 1 mg/kg intravenous over 10 seconds before extubation and remaining 1 mg/kg intravenous over 10 seconds immediately after extubation
Control
Sponsors
Fortis Hospitals Limited
Eligibility
Inclusion criteria
Inclusion criteria: 1. American Society of Anesthesiologists (ASA) physical status 1 3 2. Body mass index (BMI) less than 35kg/m2 3. Scheduled to undergo elective surgery under general anaesthesia with endotracheal intubation
Exclusion criteria
Exclusion criteria: 1. Patient refusal 2. Past history of allergy 3. History of neuromuscular disease, coagulopathy 4. Patients with severe hepatic or renal impairment 5. Haemodynamically unstable patients 6. Patients who are planned to remain intubated and mechanically ventilated or tracheostomized postoperatively 7. Pregnant or lactating women 8. Patients with active cough or history of smoking 9. History of asthma or chronic obstructive pulmonary disease 10. Difficult intubation requiring more than 3 attempts
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To measure and compare the incidence and severity of emergence cough between two groups of patients: 1. One group (A) receiving the total dose of sugammadex (2 mg/kg) intravenous over 10 seconds prior to extubation, and 2. The other group (B) receiving half of the total 2 mg/kg dose (1 mg/kg intravenous over 10 seconds) before extubation, and the remaining half (1 mg/kg intravenous over 10 seconds) immediately after extubation.Timepoint: 1. Emergence time (time period from discontinuation of all anaesthetic agents to administration of intravenous reversal agent sugammadex) 2. Extubation time (time period from intravenous administration of reversal agent sugammadex to the time at which tracheal extubation is performed) 3. 1 minute after extubation 4. 5 minutes after extubation 5. 60 minutes in the Post Anaesthesia Care Unit (PACU). | — |
Secondary
| Measure | Time frame |
|---|---|
| To measure & compare the incidence of post-extubation desaturation (oxygen saturation less than 90% on facemask) between the two groupsTimepoint: 1. 1 minute after extubation 2. 5 minutes after extubation;To measure & compare post-extubation sedation levels graded with Ramsay Sedation Score (RSS).Timepoint: 1. 1 minute after extubation 2. 5 minutes after extubation ;Incidence of severe delayed post-operative coughTimepoint: 60 minutes in the Post Anaesthesia Care Unit (PACU);Incidence of post-operative sore throatTimepoint: 60 minutes in the Post Anaesthesia Care Unit (PACU) | — |
Countries
India
Contacts
Public ContactDr Amruta Kulkarni
Fortis Hospitals Limited
Outcome results
None listed