- To evaluate the improvement in Symptoms and compare the sideffects of two radiotherapy regimens ( QUARD short vs Twice weekly) in patients being treated for Sq cell carcinoma Head and Neck region with palliative intent.

A randomized controlled trial to compare quad shot versus twice weekly radiotheraphy in squamous cell non nasopharyngeal head and neck carcinoma treated with palliative intent. - Nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/088064

Enrollment

Registered

2025-06-02

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C109- Malignant neoplasm of oropharynx,unspecified

Interventions

Intervention1: - The intervention is palliative intention radiatiotheraphy in patients of advanced head and neck carcinoma in two different regimens: - To assess and compare the toxicity in patients

Eligibility

Inclusion criteria

Inclusion criteria: Patients with locally advanced head and neck squamous cell histology biopsy proven. Performance status more than or equal to 2. Estimated survival at least 3 months. Age between 19 to 70. Stage III and IVa IVb by TNM staging. Blood parameters Hb more than 9gm/dl ANC more 1500 Platelet count more 1 lakhs SGOT/SGPT less than 3 upper limit of normal Est Cr Clear more than 30 ml/min.

Exclusion criteria

Exclusion criteria: EXCLUSION CRITERIA DISTANT METASTASES PATIENT had history of malignancy excluding melanoma within 5 years or received radiation before. Patient with uncontrolled comorbid conditions. Pregnancy or Lactation. Patient not fit to give consent.

Design outcomes

Primary

Measure	Time frame
To assess the effectiveness in terms of symptoms control of the quard shot vs twice weekly radiotherapy. To Compare the response to treatment in both arms in terms of RECIST criteria V 1.1 at 4-6 weeks from completion of Radiotherapy to assess the improvement of quality of life in terms of pain and changes in body weight.Timepoint: at 4-6 weeks from completion of Radiotherapy to assess the improvement of quality of life in terms of pain and changes in body weight.	—

Measure

Time frame

To assess the effectiveness in terms of symptoms control of the quard shot vs twice weekly radiotherapy. To Compare the response to treatment in both arms in terms of RECIST criteria V 1.1 at 4-6 weeks from completion of Radiotherapy to assess the improvement of quality of life in terms of pain and changes in body weight.Timepoint: at 4-6 weeks from completion of Radiotherapy to assess the improvement of quality of life in terms of pain and changes in body weight.

—

Secondary

Measure	Time frame
- To assess and compare the toxicity in patients receiving radiotherapy in two different regimens ( QUARD short vs Twice weekly ) by RTOG toxicity criteria for Sq cell Carcinoma H&N region treated with palliative intent. Timepoint: After 4-6 weeks after completion of radiotherapy	—

Countries

India

Contacts

Public ContactDr Abhineet Dasgupta

Institute of post graduate medical education and research

mailforadg@gmail.com8918396138

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026