Health Condition 1: J22- Unspecified acute lower respiratory infection
Conditions
Interventions
Intervention1: HFNC: High flow will be provided with the Optiflow nasal cannula
Fisher & Paykel
Healthcare, Auckland, New Zealand) with Airvo 2 (Fisher & Paykel Healthcare,
Auckland. HFNC will be initiated with a minimum flow of 30L/min with a
fraction of inspired oxygen (FiO2) o
Sponsors
Medanta Hospital
Eligibility
Inclusion criteria
Inclusion criteria: All patients who are more than 18 yrs. old with hypoxemic respiratory failure due to COVID-19 pneumonia
Exclusion criteria
Exclusion criteria: 1. Patients younger than 18 years old, patients with indication for immediate intubation. 2. Patients for whom HFNC will be used for extubation failures and those with do-not-intubate order will be excluded. 3. Patients who will be electively intubated for diagnostic or therapeutic procedures (bronchoscopy, surgery) will not be included.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the ROX index as a predictor of success of HFNC therapy for hypoxemic respiratory failure in COVID19 pneumoniaTimepoint: SOFA (10) score will be recorded once a day during the first five days of HFNC therapy. We will also record the 4C COVID mortality score. (11) Clinical respiratory variables in patients 2h, 6h, 12h, 18h, and 24h after initiation of HFNC therapy will be recorded. After the first 24 hours, the same variables will be recorded once daily until HFNC withdrawal | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the relation between ROX index & ICU stay, hospital stay, & outcomes of patientsTimepoint: SOFA (10) score will be recorded once a day during the first five days of HFNC therapy. We will also record the 4C COVID mortality score. (11) Clinical respiratory variables in patients 2h, 6h, 12h, 18h, & 24h after initiation of HFNC therapy will be recorded. After the first 24 hours, the same variables will be recorded once daily until HFNC withdrawal | — |
Countries
India
Contacts
Public ContactRajesh Chandra
Medanta Hospital
Outcome results
None listed