The efficacy of keto-dex medicine as compared to keto-lig medicine for pain management of patients undergoing keyhole surgery for surgery scar site hernia.

Comparison of analgesic efficacy of keto-dex versus keto-lig as opioid sparing maintenance analgesics in patient undergoing laparoscopic incisional hernia under entropy guided general anaesthesia: A randomized control trial - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/088012

Enrollment

135

Registered

2025-06-02

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Group1(keto-dex) ketamine and dexmedetomidine infusion: After induction of anesthesia, for group 1 (ketamine:0.2mg per kg per hour and dexmedetomidine: 0.5 g per kg per hour) infusion w

Eligibility

Inclusion criteria

Inclusion criteria: 1.Age 18 years to 60 years 2.American Society of Anaesthesiologists (ASA) physical status 1 and 2 3.Undergoing elective laparoscopic incisional hernia under general anesthesia

Exclusion criteria

Exclusion criteria: 1.Presence of any uncontrolled cardiovascular disease (hypertension, conduction block etc) 2.Presence of any cerebrovascular or neurological disease (seizure, past history of stroke etc) 3.Patient on any anti-psychotic drugs or antidepressant drugs 4.Patient on beta blocker 5.Presence of any chronic liver or kidney disease 6.Pregnant and nursing women 7.Surgery duration more than 3 hours 8.BMI more than 35 KG/M2

Design outcomes

Primary

Measure	Time frame
To compare intraoperative fentanyl consumption between two groupsTimepoint: 15 minutes,30 minutes,45 minutes,60 minutes,90 minutes,120 minutes, 150 minutes post intubation	—

Secondary

Measure	Time frame
Intra- operative haemodynamicTimepoint: 5 minute, 10 minute, 15 minute, 30 minute ,45 minute, 60 minute, 90 minute,120 minute 150 minute;Post operative analgesia requirementsTimepoint: 15 min, 30 min, 1 hour,2hours,4hours,8hours,12hours;Post operative sedation scoreTimepoint: 15 min, 30 min, 1 hour,2hours,4hours,8hours,12hours;Recovery timeTimepoint: postoperative period;Post operative nausea & vomitingTimepoint: Numeber of episodes in postoperative period	—

Measure

Time frame

Intra- operative haemodynamicTimepoint: 5 minute, 10 minute, 15 minute, 30 minute ,45 minute, 60 minute, 90 minute,120 minute 150 minute;Post operative analgesia requirementsTimepoint: 15 min, 30 min, 1 hour,2hours,4hours,8hours,12hours;Post operative sedation scoreTimepoint: 15 min, 30 min, 1 hour,2hours,4hours,8hours,12hours;Recovery timeTimepoint: postoperative period;Post operative nausea & vomitingTimepoint: Numeber of episodes in postoperative period

—

Countries

India

Contacts

Public ContactSudhansu Sekhar Nayak

All India Institute Of Medical Sciences , New Delhi

nayak.sudhansusekhar@gmail.com8874756836

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026