Health Condition 1: C148- Malignant neoplasm of overlappingsites of lip, oral cavity and pharynx
Conditions
Interventions
Intervention1: Nil: Nil
Sponsors
Dr Akanksha Tiwari
Eligibility
Inclusion criteria
Inclusion criteria: Group 1 Patients having habit of betel quid chewing with areca nut chewing, smoking and smokeless forms of tobacco consumption without any clinical evidence of lesion in oral cavity aged between 20 to 80 years. Group 2 Patients with any inflammatory and infectious oral conditions like moderate to severe periodontitis, ulcers aged between 20 to 80 years. Group 3 Inclusion criteria for Oral Potentially Malignant Disorders- 1 Clinically diagnosed cases of leukoplakia/non homogenous leukoplakia and or erythroplakia with histopathological diagnosis of hyper or para keratosis with or without dysplasia falling withing age group of 20-80 years 2 Clinically diagnosed cases of OSMF falling withing age group of 20-80 years. 3 Clinically and histo-pathologically proven cases of erosive variant of oral lichen planus of patients within age group 20-80 years. Inclusion criteria for oral cancer group- 4 Histopathologically diagnosed cases of Oral squamous cell carcinoma, Invasive carcinoma and carcinoma insitu in patients aged between 20-80 years. Inclusion criteria for control group- Patients with no oral habits of tobacco consumption, patients in good systemic health, not taking any medication for systemic illnesses aged between 20-80 years. Patients who demonstrate good oral hygiene and were free from any oral infection or inflammation like oral ulcers or inflamed gums aged between 20-80 years.
Exclusion criteria
Exclusion criteria: Patients who do not give consent to participate in the study. Patients who have underlying systemic diseases, other malignancies apart from Oral squamous cell carcinoma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Up regulation and/or down regulation of these salivary defensin biomarkers may validate its efficacy as a useful early screening or diagnostic tool.Timepoint: Outcomes will be assessed quarterly and Final Outcome will be assessed after 18 months | — |
Secondary
| Measure | Time frame |
|---|---|
| NILTimepoint: NIL | — |
Countries
India
Contacts
Public ContactDr Akanksha Tiwari
Manipal College Of Dental Sciences,Manipal
Outcome results
None listed