Speeding up braces with platelet-rich plasma.

The effect of locally administered platelet-rich plasma injection on the acceleration of orthodontic tooth movement: A Split mouth study - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/05/087949

Enrollment

Registered

2025-05-30

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: X- New Technology

Interventions

Intervention1: Platelet Rich Plasma: Intervention: The intervention involves the use of Platelet-Rich Plasma (PRP) prepared from the patient s own blood. A small amount of venous blood will be collect

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients aged more than 12 years 2) Patients with moderate crowding in the anterior maxilla where extraction is indicated 3) Patients with no history of orthodontic treatment 4) patients with no history of systemic diseases (specifically blood-related disorders)

Exclusion criteria

Exclusion criteria: 1) Patients who had blood-related disorders 2) Patients took anticoagulant drugs that affected bone metabolism, for example, heparin, warfarin, NSAIDs, cyclosporine, glucocorticoids, medroxyprogesterone acetate, and thyroid hormones. 3) Patients with severe tooth displacement like ectopic canine 4) Previous history of orthodontic treatment

Design outcomes

Primary

Measure	Time frame
The primary outcome is the rate of orthodontic tooth movement during the en-masse retraction phase. Tooth movement will be measured at baseline, 3 weeks, 6 weeks, and 9 weeks on both the PRP-treated and control sides using standardized intraoral measurements on dental casts or intraoral photographs. The difference in tooth movement between the two sides will be analyzed to assess PRPs effectiveness in accelerating tooth movement. This outcome is used in the sample size calculation.Timepoint: at baseline, 3 weeks, 6 weeks, 9 weeks	—

Measure

Time frame

The primary outcome is the rate of orthodontic tooth movement during the en-masse retraction phase. Tooth movement will be measured at baseline, 3 weeks, 6 weeks, and 9 weeks on both the PRP-treated and control sides using standardized intraoral measurements on dental casts or intraoral photographs. The difference in tooth movement between the two sides will be analyzed to assess PRPs effectiveness in accelerating tooth movement. This outcome is used in the sample size calculation.Timepoint: at baseline, 3 weeks, 6 weeks, 9 weeks

—

Secondary

Measure	Time frame
Mean amount of canine retraction (in mm) on the PRP-injected side compared to the control sideTimepoint: 21 days 42 days 63 days	—

Countries

India

Contacts

Public ContactDr Amit Handa

Aditya Dental College Beed

handaamit1986@gmail.com9960573397

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026