Health Condition 1: F411- Generalized anxiety disorder
Conditions
Sponsors
Dr Mansee Thakur
Eligibility
Inclusion criteria
Inclusion criteria: Patients diagnosed by Psychiatrist for anxiety will be included in the study. Patients screened by DASS-21 score 8 and 9 for mild and 10 to 14 for moderate anxiety, HAM-A scores of less than 17 indicating mild severity, 18 24 mild to moderate severity and PHQ-9 score of 1-4 indicating minimal depression, Gad-7 score 5 to 9 for mild and 10 to 14 for moderate anxiety. Patients agreed to follow meditation protocol and willing to participate.
Exclusion criteria
Exclusion criteria: Individuals presented with Disorder of Sex Development. History of convulsion or epilepsy during the last 6 months before the study History of drug abuse. Having received any psychiatric or psychological therapies during the month before the study. Patients having a known history of Schizophrenia, Bipolar disorder, Personality disorder, Anxiety disorder, Mood disorder, Obsessive compulsive disorder, Dissociative disorder, Panic disorder, Depression and any other severe mental health condition. Patients with metabolic disorders (diabetes, hypertension, and obesity), need oxygen supply or ventilation support and pregnant women or cancer.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Mean depression scores 2. Mean anxiety scores 3. Mean stress scores 4. PER1, CRY1, and BMAL1 gene expression 5. anxiety-related genes 5-HT2A, FKBP5, and MAOATimepoint: 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Improved Mental Health: Significant reductions in depression, anxiety, and stress in meditation practitioners. 2. Enhanced Circadian Regulation: Positive effects on circadian rhythm patterns and biological clock regulation through changes in PER1, CRY1, and BMAL1 gene expression meditation practitioners. 3. Altered Gene Expression: Modulation of anxiety-related genes 5-HT2A, FKBP5, and MAOA, potentially reducing anxiety through molecular pathways meditation practitioners. 4. Psychological Well-being: Overall improvements in mental health parameters, highlighting the therapeutic potential of Heartfulness meditation. 5.Integrated Mental-Molecular Impact: Evidence supporting the holistic effects of meditation such as Heartfulness on both psychological states and molecular mechanisms related to mental health. Timepoint: 12 weeks | — |
Countries
India
Contacts
Public ContactMs Suparna Deepak
MGM School of Biomedical Sciences, MGMIHS, Navi Mumbai
Outcome results
None listed