Health Condition 1: K746- Other and unspecified cirrhosis ofliver
Conditions
Interventions
Intervention1: Use of reconstituted 1/2 Normal saline with added bicarbonate as primary intravenous fluid during entire liver transplant surgery: In each 500 ml of 1/2 NS , 30 ml of 8.4 % sodabicarbon
Sponsors
Amrita Institute Of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Adult patients undergoing elective liver transplant surgery
Exclusion criteria
Exclusion criteria: 1.Renal dysfunction with creatinine more than 1.5 mg/dl 2. Alkalosis with bicarbonate more than 27 mmol/L 3. Hyperkalemia with K more than 4.5 mEq/L
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of bicarbonate levels between both groups at given time points during surgery Timepoint: 1. T0 Baseline prior to surgery 2. T1 2 hours in dissection phase 3.T2 Start of Anhepatic Phase 4.T3 Prior to Implant 5.T4 10 min post reperfusion 6.T 5 At time of shifting | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. pH, Base excess, Lactate, Sodium, Potassium and Chloride levels 2. Need to change fluid Half NS or Plasmalyte 3. Need additional potassium supplementation 4. Total volume of fluids 5. Duration of surgery Timepoint: T0 Baseline prior to surgery 2. T1 2 hours in dissection phase 3.T2 Start of Anhepatic Phase 4.T3 Prior to Implant 5.T4 10 min post reperfusion 6.T 5 At time of shifting | — |
Countries
India
Contacts
Public ContactKrishnapriya KK
Amrita Institute of Medical Sciences
Outcome results
None listed