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study to find out whether repeated checks of pupil reactions, optic nerve size, and white blood cell levels can help predict brain damage after a brain aneurysm rupture

Study of the correlation between serial measurements of Neurological Pupil Index (NPi), Optic Nerve sheath diameter (ONSD), WBC count and occurrence of delayed cerebral ischemia (DCI) in aneurysmal Sub Arachnoid Haemorrhage-A prospective observational study. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/05/087810
Enrollment
50
Registered
2025-05-28
Start date
Unknown
Completion date
Unknown
Last updated
2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I609- Nontraumatic subarachnoid hemorrhage, unspecified

Interventions

Intervention1: Nil: Nil

Sponsors

Academic division, Sree Chitra Tirunal Institute For Medical Sciences and Technology
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Adult patients admitted and undergoing neurosurgical or interventional radiological procedures at Sree Chitra Tirunal Institute for Medical Sciences and Technology for aneurysmal sub arachinoid hemorrhage. 2.ASA (American Society of Anesthesiologists) class 1 2 and 3 3.SAH Hunt and Hess grades of I,II,III and IV 4.Aneurysm of anterior circulation.

Exclusion criteria

Exclusion criteria: 1.Patient refusal or refusal by patient bystanders 2.Patients with previous SAH 3.Absence of feasibility of performing NPi and ONSD assessment on the eye due to either pupillary disease, oculomotor nerve damage ,disease or significant periorbital oedema where pupillary assessment is not possible. 4.History of previous neurosurgery or endovascular neurological procedures 5.History of continued antiinflammatory drug use in the previous 6 months 6.Acute respiratory failure (pneumonia, acute lung injury, ARDS) 7.Progressive neuromuscular disease 8.Pregnant and lactating mothers 9.Heart failure or severe heart disease. 10.Posterior circulation aneurysms

Design outcomes

Primary

MeasureTime frame
1.To use serial NPi for early detection of delayed cerebral ischemia in patients of aneurysmal sub arachnoid hemorrhage using modified rankin scoreTimepoint: at discharge and 3 months after discharge—

Secondary

MeasureTime frame
1.To assess correlation between serial NPi and incidence of vasospasm. 2.To examine the correlation between NPi and ONSD to already established prognostic indices like CT criteria, WBC count, and TCD in the determination of DCI. 3.Correlation between NPi and neurological outcome Timepoint: 21 months—

Countries

India

Contacts

Public ContactDr Parvathy D

Sree Chitra Institute For Medical Sciences and Technology

parvathydin@gmail.com9074454058

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026