Health Condition 1: C00-C14- Malignant neoplasms of lip, oral cavity and pharynx
Conditions
Interventions
Intervention1: Hypofractionated Radiotherapy: Hypo fractionated radiotherapy with 55Gy in 20 fractions, 2.75Gy per fraction, single fraction per day, 5 fractions per week for a total of 4 weeks.
Contr
Sponsors
Dr Ankur Saha
Eligibility
Inclusion criteria
Inclusion criteria: All histological and/or cytological proven cases of primary malignancy of Squamous cell carcinoma of the oral cavity. Unresectable and Locally advanced disease. Age between 18 to 70 years, with Performance Status ECOG 0,1,2. Previously untreated for any type of cancer. Normal haematological parameters. Patients willing to participate in the study with a written and informed consent.
Exclusion criteria
Exclusion criteria: Previous history of Radiotherapy in Head and Neck region. Patients with collagen vascular disease or any other systemic comorbidities or severe uncontrolled infection, which may alter treatment outcome. Pregnant or nursing women. Patients who had impaired liver function, bone marrow suppression & renal dysfunction. Recurrent disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response assessment Timepoint: at baseline, after completion of radiation, at 3 months, at 6 months, at 9 months, at 12 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessment of ToxicitiesTimepoint: at baseline, after completion of radiotherapy, 3 months, 6 months, 9 months, months | — |
Countries
India
Contacts
Public ContactDr Amitabha Manna
Institute of Post Graduate Medical Education and Research and SSKM Hospital
Outcome results
None listed