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To Study the effect of new intracanal medicament to reduce pain during root canal treatment

Comparative Evaluation Of Three Different Intracanal Medicaments On The Interappointment Pain: A Randomized Clinical Trial Study - NIL

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/05/087796
Enrollment
45
Registered
2025-05-28
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K044- Acute apical periodontitis of pulpal origin

Interventions

Intervention1: Modified Triple antibiotic paste: Powdered Clindamycin, Metronidazole, Ciprofloxacin in 1:1:1 ratio mixed with normal saline in 3:1 ratio will be Placed for 2 weeks. Intervention2: Feru

Sponsors

Dr Labdhi Maloo
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Single-rooted Maxillary/Mandibular teeth. Non-contributory medical history (patient can be seen for regular dental appointments). Tooth with adequate remaining tooth structure for proper isolation with a rubber dam.No history of previous endodontic treatment on the tooth.Clinical examination: Teeth with response to pain and suggestive of Tenderness on percussion positive. Radiographic examination: Teeth in which lesion involving pulp, loss of lamina dura, and widening of PDL space.

Exclusion criteria

Exclusion criteria: Immunocompromised Patients, self-reported pregnancy, patients with multiple drug allergies. Patients with known hypersensitivity to ferumoxytol nanoparticles or any iron products. Patients who are scheduled for MRI for the head region within three months after Fer nanoparticles application. Periodontal changes. Radiographic presence of resorptive processes. Teeth with sinus opening, mobility, cracked tooth, furcal radiolucency, internal or external resorption, and periapical lesion. Adverse reaction reported to any dental material. Uncooperative patient. If one of the inclusion criteria is not met

Design outcomes

Primary

MeasureTime frame
Outcome is to compare and evaluate three different intracanal medicaments and their interappointment pain pain at 4, 12, 24, and 48 hoursTimepoint: 4, 12, 24, and 48 hours

Secondary

MeasureTime frame
Clinical and Radiographic EvaluationTimepoint: 4, 12, 24, and 48 hours

Countries

India

Contacts

Public ContactDr Rashmi Nair

Chhattisgarh Dental College and Research Institute, Sundra, Rajnandgaon 491441

labdhimaloo28235@gmail.com7744939695

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026