Does using tetracycline fiber early in gum treatment improve bone healing surgery results? A study comparing healing, radiographs, and bacterial count in gum bone defects

Evaluation of tetracycline local drug delivery during initial periodontal therapy on the outcomes of regenerative surgery using xenograft and PRF membrane in periodontal osseous defects - A comparative clinicoradiographic and microbiological study - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/05/087762

Enrollment

Registered

2025-05-28

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Controlled release tetracycline fiber (periodontal plus AB), Xenograft [OSSEOGRAFT] , platelet rich fibrin (S-PRF)membrane: In test site: As an adjunct to scaling and root planing wil

Eligibility

Inclusion criteria

Inclusion criteria: Subjects belonging to the age group of 30 to 65 years of both sexes Subjects having atleast one posterior tooth in two quadrants having probing pocket depth of 5mm and at least 5mm of clinical attachment loss or greater Radiographic evidence of an angular bone defect Patient who are willing for participation and follow up

Exclusion criteria

Exclusion criteria: Patients with systemic disease affecting periodontal health such as uncontrolled diabetes, immunodeficiency or osteoporosis History of periodontal surgery or locally delivered antimicrobial therapy in the past 6 months Allergic to tetracycline Smokers or individuals using tobacco products Pregnant or lactating women Patients with poor oral hygiene compliance and severe periodontal destruction

Design outcomes

Primary

Measure	Time frame
To compare the quantitative measurements of changes in radiographic bone fillTimepoint: at baseline, and 3 months and 6 months post-operatively.	—

Secondary

Measure	Time frame
To evaluate bacterial colony forming units (CFU) after initial therapy, prior to surgery, and 6 months post-operatively.Timepoint: To evaluate bacterial colony forming units (CFU) after initial therapy, prior to surgery, and 6 months post-operatively.	—

Countries

India

Contacts

Public ContactDr Majo Ambooken

Mar Baselios Dental College

majoambooken@mbdc.edu.in9447268750

Outcome results