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comparsion of efficacy of Simvastatin with Human Graded Calcium Sulphate Hemihydrate in Socket Preservation After Third Molar Surgery: A Randomized Controlled Trial

Comparative Evaluation of Efficacy of Simvastatin with Human Graded Calcium Sulphate Hemihydrate in Socket Preservation after Surgical Removal of Impacted Mandibular Third Molar: A Randomized Controlled Trial. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/05/087720
Enrollment
60
Registered
2025-05-27
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Z768- Persons encountering health services in other specified circumstances

Interventions

Intervention1: tablet Simvastatin (10 mg) for socket preservation: Study group 1 after the surgical removal of impacted mandibular third molar participant will receive a tablet Simvastatin (10 mg) t

Sponsors

Yash Adiwal
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients between age of 18-45 years of both genders. 2) Patients indicated for surgical removal of impacted mandibular third molar. 3) Healthy patients falling under ASA I and ASA II 4) Subjects able and willing to provide written informed consent and compliant with study procedure.

Exclusion criteria

Exclusion criteria: 1) Patients with mouth opening less than 30mm. 2) Patients with allergy with NSAIDS, Penicillin 3) Patients having history of drug abuse. 4) Patients having history of liver disorder and kidney disorder 5) Patients having any systemic or local immunodeficiency. 6) Patient is under regular analgesics and anti-depressants. 7) Having any blood coagulation impairment. 8) Presence of any acute oral infection. 9) Have been suffering with uncontrolled diabetes or other systemic diseases. 10) Having previous history of radiation therapy in the head and neck region. 11) Pregnant and nursing women.

Design outcomes

Primary

MeasureTime frame
1. PAIN 2. SWELLING 3. TRISMUS 4. BONE REGNERATIONTimepoint: PAIN, SWEELING AND TRISMUS ON 1ST , 3RD AND 7TH DAY AND BONE Regeneration on 0, 3rd and 6th month—

Secondary

MeasureTime frame
ANY OTHER COMPLICATIONTimepoint: ON 1ST , 3RD AND 7TH DAY—

Countries

India

Contacts

Public ContactShallu Bansal

Geetanjali Dental & Research Institute

drshallu23@yahoo.com9116155666

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026