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Hyaluronic Acid Gel versus placebo Gel on MMP-9 biomarker levels in the sulcus and Implant stability.

Efficacy of Hyaluronic Acid Gel on MMP-9 levels in Peri-implant sulcular fluid and Dental Implant Stability: A Split moth study - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/05/087702
Enrollment
30
Registered
2025-05-27
Start date
Unknown
Completion date
Unknown
Last updated
2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K084- Partial loss of teeth

Interventions

Intervention1: Hyaluronic Acid Gel: Hyaluronic acid gel will be used only once at baseline while placing the implant. The placebo gel will be placed only once at baseline during implant placement. The

Sponsors

Dr.Shruti Ananya
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Systemically healthy patients. 2. Mandibular edentulous sites with adequate bone volume and height. 3. Non-smokers.

Exclusion criteria

Exclusion criteria: 1. Patients with poor oral hygiene and periodontal disease. 2. Uncontrolled systemic disease affecting bone healing and blood dyscrasias. 3. Patient on bisphosphonates. 4. Pregnant and lactating females. 5. Tobacco in all forms. 6. Patients with parafunctional habits like bruxism. 7. Patients with history of chemotherapy or radiotherapy in the last 6 months.

Design outcomes

Primary

MeasureTime frame
There is difference seen in the MMP-9 levels and implant stability on application of Hyaluronic acid gel around dental implants.Timepoint: MMP-9 at 104 days and 180 days. Implant stability at baseline and 180 days.—

Secondary

MeasureTime frame
nilTimepoint: nil—

Countries

India

Contacts

Public ContactDrShruti Ananya

Manav Rachna Dental College SDS MRIIRS

pooja.sds@mrei.ac.in9891175112

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026