Comparison of effect of spinal anaesthesia with two different drugs-Dexmedetomidine vs clonidine as premedication to spinal anaesthesia for lower abdominal and lower limb surgeries

Comparative study of intravenous clonidine versus intravenous dexmedetomidine as premedication to intrathecal 0.5% bupivacaine (hyperbaric) in patients undergoing lower abdominal and lower limb surgeries- a prospective randomised,double blind study. - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/05/087696

Enrollment

Registered

2025-05-27

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

Intervention1: Dexmedetomidine: Dexmedetomidine 0.5mcg/kg intravenous given as premedication to 0.5%bupivacaine(hyperbaric) Control Intervention1: Clonidine: Clonidine 0.1mcg/kg given as premedication

Eligibility

Inclusion criteria

Inclusion criteria: 1.American society of anaesthesiologist (ASA) grade I and II. 2. Scheduled for lower abdominal and lower limb surgeries. 3.Both elective and emergency procedures.

Exclusion criteria

Exclusion criteria: 1.Patient aged less than 18years and more than 60years 2.Drug allergic reaction,pregnancy,Coagulopathy,major hepatic,renal and cardiovascular dysfunction 3.Bradycardia of heart rate less than 50 beats per minute and tachycardia of heart rate more than 100 beats per minute 4.obese of BMI more than 30kilogram per meter square

Design outcomes

Primary

Measure	Time frame
To compare onset and duration of motor and sensory block To compare the duration of analgesiaTimepoint: 120 mins	—

Secondary

Measure	Time frame
To assess and compare the sedation score Ramsay sedation score To assess the shivering intraoperatively and postoperatively between both groups To compare the side effectsTimepoint: 120 mins	—

Countries

India

Contacts

Public ContactProf DR ANAND

Chettinad hospital and research institute

dranandmurugan@gmail.com9444486183

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026