Health Condition 1: R00-R99- Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
Conditions
Interventions
Intervention1: Selective digestive decontamination: non absorbable gastrointestinal suspension and paste of colistin, tobramycin and nystatin
Topical Application (Oropharyngeal):
- 0.5g oral past
Sponsors
NONE
Eligibility
Inclusion criteria
Inclusion criteria: Critically ill patients requiring mechanical ventilation Expected to require mechanical ventilation for at least 48 hours (APACHE IV) Admitted to the intensive care unit (ICU) Informed consent from patients or their legal representatives
Exclusion criteria
Exclusion criteria: Age less than 12 years Intubated or mechanically ventilated 48 hours before presentation to the study setting. Pneumonia at the time of presentation Patients with known allergies to study medications Pregnant or breastfeeding women Patients with a history of selective digestive decontamination Active tuberculosis Known immunocompromised status inability to enroll within 4 hours of endotracheal intubation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Outcome: Occurrence of Ventilator associated pneumonia in both the groups during index hospital admission Timepoint: every 48 hourly till the patient is extubated or develops ventilator associated pneumonia | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes: Duration of endotracheal intubation All cause mortality within 28 days of hospital admission Development of antimicrobial resistance length of hospital stayTimepoint: every 48 hourly | — |
Countries
India
Contacts
Public ContactNishit Kumar Sahoo
PGIMER, Chandigarh
Outcome results
None listed