Effect of nitroglycerine injection for easy access of radial artery for monitoring in patients undergoing heart surgery

Effects of Subcutaneously Infiltrated Nitroglycerin on Diameter, Palpability, Ease-of-Puncture, and Pre-Cannulation Spasm of the Radial Artery in Patients Undergoing Cardiac Surgery post radial angiography: A Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/05/087575

Enrollment

Registered

2025-05-26

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I52- Other heart disorders in diseasesclassified elsewhere

Interventions

Intervention1: Subcutaneous Nitroglycerin (NL): Patients will receive subcutaneous nitroglycerin infiltration (dose: 500 mcg diluted in 1 mL normal saline + 2ml of 2% lignocaine) at the radial artery

Eligibility

Inclusion criteria

Inclusion criteria: (a) Patients aged 18 75 years scheduled for cardiac surgery. (b) Patients who underwent radial angiography at least 7 days prior. (c) Radial artery deemed suitable for cannulation on pre-procedural ultrasound. (d) Hemodynamically stable patients.

Exclusion criteria

Exclusion criteria: (a) Radial artery occlusion or severe calcification detected on ultrasound (b) Allergy or contraindication to nitroglycerin (c) Severe hypotension (SBP less than 90 mmHg) or hemodynamic instability (d) Use of vasodilators within the past 6 hours (e) Bleeding disorders or local skin infections at the infiltration site

Design outcomes

Primary

Measure	Time frame
(a)Change in radial artery diameter (mm) before and after NTG + lignocaine or Saline + lignocaine (measured via ultrasound)Timepoint: at baseline, after one minute	—

Secondary

Measure	Time frame
(b) Palpability of the artery (Scored on a 5-point palpation scale: 1= non-palpable, 2= feeble, 3 = palpability same after infiltration, 4= palpability became better after infiltration, 5= pulse became bounding after infiltration) (c) Ease-of-puncture: a. Number of attempts required for successful cannulation b. Time needed for successful access of radial artery (d) Pre-cannulation radial artery spasm: a. Subjective assessment by the operator (graded as absent, mild, moderate, or severe) Timepoint: at baseline, after one minute of injection	—

Measure

Time frame

(b) Palpability of the artery (Scored on a 5-point palpation scale: 1= non-palpable, 2= feeble, 3 = palpability same after infiltration, 4= palpability became better after infiltration, 5= pulse became bounding after infiltration) (c) Ease-of-puncture: a. Number of attempts required for successful cannulation b. Time needed for successful access of radial artery (d) Pre-cannulation radial artery spasm: a. Subjective assessment by the operator (graded as absent, mild, moderate, or severe) Timepoint: at baseline, after one minute of injection

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Countries

India

Contacts

Public ContactG S Ghotra

Army Hospital Research and Referral

gpsghotra5@gmail.com7261955514

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026