Health Condition 1: O- Medical and Surgical Health Condition 2: O- Medical and Surgical
Conditions
Interventions
Intervention1: Intranasal Insulin: Long acting Intranasal Insulin 20 IU to be administered twice daily in ICU patients for the period of 10 days or till discharge from ICU whichever is earlier
Control
Sponsors
DrMeghna Kahlon
Eligibility
Inclusion criteria
Inclusion criteria: Both male and female aged 18-70 years with expected ICU stay of more than 24 hours
Exclusion criteria
Exclusion criteria: Already delirious or pre-existing cognitive dysfunction Pregnant patients Patients with irreversible brain damage or acute brain injury Hepatic encephalopathy or liver cirrhosis with a Child Pugh Score B or C Comatose patients who cannot be assessed for delirium Patients in whom intranasal drug administration is contraindicated Patients with hypoglyceamia at the tme of presentation RASS -4 OR -5
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of deliriumTimepoint: Within the first 10 ICU days | — |
Secondary
| Measure | Time frame |
|---|---|
| The number of positive CAM-ICU counts Duration of delirium Duration of mechanical ventilation Length of ICU stay Length of hospital stay Duration of intubation Successful extubation Need for antipsychotics/sedatives and dosages used ICU mortality Any adverse side effects due to intranasal insulinTimepoint: within the period of 10 days or discharge | — |
Countries
India
Contacts
Public ContactVIKAS SAINI
PGIMER CHANDIGARH
Outcome results
None listed