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Evaluation of clot waveform in a commonly used clotting test APTT to detect clotting abnormalities DIC and to predict death in participants with severe infection admitted in surgical ICU

Utility of APTT waveform analysis for identification of DIC and prediction of mortality in patients with sepsis admitted to Surgical ICU - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/05/087522
Enrollment
500
Registered
2025-05-23
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R791- Abnormal coagulation profile

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil Intervention4: Nil: Nil

Sponsors

Christian medical college
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients admitted to SICU with sepsis of either gender above 18 years of age, sepsis was diagnosed as per sepsis -3 definition proposed by 2016 SCCM/ESICM

Exclusion criteria

Exclusion criteria: Acute and chronic liver disease. Active thrombosis Malignancy/leukemia Autoimmune diseases Patients on antiplatelets/anticoagulants. Congenital platelet and coagulation/bleeding disorders. Pregnant patients

Design outcomes

Primary

MeasureTime frame
To compare DIC and mortality rate among Biphasic or abnormal waveform positive and negative patientTimepoint: 28 days from the day of ICU admission—

Secondary

MeasureTime frame
Association of biphasic or abnormal waveform with Duration of hospital length of stay Timepoint: 28 days from the day of ICU admission;Association of biphasic or abnormal waveform with positive bacterial culture resultsTimepoint: 28 days from the day of ICU admission;Association of biphasic or abnormal waveform with number of blood products transfusionTimepoint: 28 days from the day of ICU admission—

Countries

India

Contacts

Public ContactVijayavani P

Christian Medical College

georgekurian14@gmail.com9655594316

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026