Health Condition 1: G20- Parkinsons disease Health Condition 2: G24- Dystonia Health Condition 3: F34- Persistent mood [affective] disorders Health Condition 4: F42- Obsessive-compulsive disorder Health Condition 5: F95- Tic disorder
Conditions
Interventions
Intervention1: Tractography-based targeting of Deep Brain Stimulation electrodes and programming of Implantable Pulse Generator: The patient will undergo Magnetic Resonance Imaging (MRI) as per our De
2) tractography-based target. For tractography-based targeting, a combination of FSL and BRAINLab planning algorithms will be used. Here, we will select the point (region of the target) with the maxim
Sponsors
Jaslok Hospital and Research Centre
Eligibility
Inclusion criteria
Inclusion criteria: Population - Patients diagnosed with Parkinson s Disease, Dystonia, Depression, Obsessive-Compulsive Disorder, or Tourette Syndrome as per International Classification of Diseases (ICD)-10, unresponsive to the standard of care pharmacotherapy for at least 6 months. Inclusion and Exclusion Criteria - - The patient must be fit for general anesthesia (without or with ongoing medications). - The patient must meet specific diagnostic criteria for undergoing DBS: 1) as per the core Assessment Program for Surgical Interventional Therapies in Parkinson s Disease (CAPSIT-PD) for Parkinson s Disease and 2) Disease severity severe as per clinical assessment for other pathologies.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anatomical difference between the direct and tractography-based DBS targetsTimepoint: Within 15 days of surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Difference in the clinical efficacy of standard of care and tractography-based programming of the Implantable Pulse GeneratorTimepoint: 1 month after IPG Programming | — |
Countries
India
Contacts
Public ContactProf Dr Paresh K Doshi
Jaslok Hospital and Research Center, Mumbai
Outcome results
None listed