A Study Comparing Sugar Water (Dextrose) and Steroid Injections for Knee Joint PainInjections for Pain and Function in Knee Osteoarthritis

Comparative Effects of Intra-articular Dextrose Prolotherapy and Intra-articular Triamcinolone Acetonide on Pain and Function in Knee Osteoarthritis: A Randomized Controlled Trial. - NIL

Status

Recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/05/087473

Enrollment

112

Registered

2025-05-23

Start date

Unknown

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M179- Osteoarthritis of knee, unspecified

Interventions

Intervention1: Intra-articular Triamcinolone Acetonide: The comparator in this study is intra-articular triamcinolone acetonide, a corticosteroid drug administered in the form of an injection. Partici

Eligibility

Inclusion criteria

Inclusion criteria: Adults aged 18 years or older Radiologically confirmed knee osteoarthritis (Kellgren-Lawrence Grade II to IV) Experiencing moderate to severe knee pain Able to walk unassisted or with minimal assistance Willing to participate in the study, receive injections, and attend follow-up visits

Exclusion criteria

Exclusion criteria: Previous knee surgery within the past 6 months Presence of inflammatory joint diseases (e.g., rheumatoid arthritis) Active infection in or around the knee joint Known allergy to dextrose or triamcinolone acetonide Untreated blood clotting disorders Pregnancy or breastfeeding

Design outcomes

Primary

Measure	Time frame
1.To assess the change in pain scores between the dextrose prolotherapy and triamcinolone acetonide groups in VAS score 2.To evaluate the changes in functional outcomes in WOMAC following dextrose prolotherapy compared to triamcinolone acetonide injections Timepoint: (Week 0), Week 4, Week 12, and Week 24	—

Secondary

Measure	Time frame
I. To monitor and compare the incidence of adverse events between the dextrose prolotherapy and triamcinolone acetonide groups. II. To assess quality of life in SF 36 scale outcomes following dextrose prolotherapy versus triamcinolone acetonide injections. III. To evaluate the changes in Quadriceps hamstring ,tibilais muscles thickness measurement using ultrasound IV. To evaluate the changes in Surface electromyography (sEMG) for muscle activation patterns during gait analysis V. To evaluate the changes in Gait analysis using gait analysis system VI. Assessing changes in femoral Cartilage thickness with ultrasound Timepoint: (Week 0), Week 4, Week 12, and Week 24	—

Measure

Time frame

I. To monitor and compare the incidence of adverse events between the dextrose prolotherapy and triamcinolone acetonide groups. II. To assess quality of life in SF 36 scale outcomes following dextrose prolotherapy versus triamcinolone acetonide injections. III. To evaluate the changes in Quadriceps hamstring ,tibilais muscles thickness measurement using ultrasound IV. To evaluate the changes in Surface electromyography (sEMG) for muscle activation patterns during gait analysis V. To evaluate the changes in Gait analysis using gait analysis system VI. Assessing changes in femoral Cartilage thickness with ultrasound Timepoint: (Week 0), Week 4, Week 12, and Week 24

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Countries

India

Contacts

Public ContactDr Ravi Gaur

All India Institute of Medical Sciences (AIIMS), Jodhpur

ravisms80@gmail.com9947332918

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026