Health Condition 1: G936- Cerebral edema
Conditions
Interventions
Intervention1: Ketamine-Dexmedetomidine: Intravenous Ketamine at the dose of 1-5mg/kg/hr and Intravenous dexmedetomidine at the dose of 0.3-0.75 mcg/kg/hr to patients of severe traumatic brain injury
Sponsors
Postgraduate Institute of Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: a) Patients between age group 18 years to 65 years with severe TBI b) Severe TBI patients for conservative management c) Radiological evidence of raised ICP - Marshall CT score more than 2
Exclusion criteria
Exclusion criteria: a) Patients with thrombocytopenia (platelet count less than 100000 per mm3) or coagulopathy(INR more than 1.5) b) Polytrauma with Injury severity Score more than 25 c) Patient with unstable hemodynamics d) Infection at the proposed site of ICP catheter insertion e) Patients included in the study who undergo decompressive hemicraniectomy in the course of ICU management.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time spent in Maintaining of Cerebral perfusion pressure above 60mm Hg during the first 48 hours of either sedative regimen.Timepoint: from admission till completion of 48hrs of sedative regimen | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of Cerebral perfusion pressure below normal values (CPP excursion)Timepoint: Tfrom admission till completion of 48hrs of sedative regimen;Duration of Intracranial pressure above normal values (ICP crisis)Timepoint: from admission till completion of 48hrs of sedative regimen;TCD Mean pulsatility index values more than 1.4 at pre-defined time intervalTimepoint: from admission till completion of 48hrs of sedative regimen;Emergency neurosurgical intervention as rescue measures.Timepoint: from admission till death/discharge;GCS at discharge from ICUTimepoint: upon discharge from ICU;Incidence of mortalityTimepoint: from admission till death/discharge | — |
Countries
India
Contacts
Public ContactDr Kajal Jain
Post Graduate Institute of Medical Education and Research
Outcome results
None listed