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Difference in requirement of muscle relaxant drugs during surgery between two methods of monitoring.

Comparison between fixed interval and tof guided cisatracurium administration in terms of residual neuromuscular blockade - a randomized clinical study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/05/087412
Enrollment
80
Registered
2025-05-22
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K353- Acute appendicitis with localizedperitonitis Health Condition 2: K812- Acute cholecystitis with chronic cholecystitis Health Condition 3: N202- Calculus of kidney with calculus of ureter Health Condition 4: H661- Chronic tubotympanic suppurative otitis media Health Condition 5: K149- Disease of tongue, unspecified Health Condition 6: C509- Malignant neoplasm of breast of unspecified site Health Condition 7: C148- Malignant neoplasm of overlappingsites of lip, oral cavit

Interventions

Intervention1: administration of cisatracurium based on Train of four neuromuscular monitoring: during perioperative period the muscle relaxation will be provided by intermittent dose of cisatracurium

Sponsors

NIL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 18-60 years of either sex, willing to participate, ASA PS 1 to 3, all surgical procedures with approximate duration of 2-4 hours posted for general anaesthesia with endotracheal intubation and controlled ventilation will be enrolled in the study.

Exclusion criteria

Exclusion criteria: Patients with h/o epilepsy, neuromuscular disorder, BMI> 35kg/m2.

Design outcomes

Primary

MeasureTime frame
To assess and compare the residual neuromuscular blockade with TOFR at 15, 30, 45, and 60 minutes after extubation.Timepoint: To assess and compare the TOFR at 15, 30, 45, and 60 minutes after extubation.—

Secondary

MeasureTime frame
1.To assess & compare the time taken to achieve TOF count of 4 after the last dose of cis atracurium at the end of the surgery 2.To assess & compare the time taken to achieve TOFR more than or equal to 0.9 after administration of reversal agent at the end of anaesthesia. 3.To assess & compare the total dose of cis-atracurium used at the end of the surgery. 4.To assess & compare the ease of swallowing of 10 ml of saline in the PACU at 15,30,45 & 60minutes.Timepoint: 1.at the end of the surgery 2. at the end of anaesthesia. 3. at the end of the surgery. 4. at 15,30,45,and 60 minutes post surgery in the PACU.—

Countries

India

Contacts

Public ContactRani p

Mahatma gandhi medical college and research institute

anaesrani@gmail.com9443116908

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026