Health Condition 1: F33- Major depressive disorder, recurrent
Conditions
Interventions
Intervention1: DEXMEDETOMIDINE + ECT: Patient in the dex group will be given dexmedetomidine 0.5 mcg per kg body weight , before giving induction agent that is propofol, before the ECT procedure. 6 se
Sponsors
All India Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 55 years. Sex: all genders. 2. Diagnosed primarily with depressive disorder as per ICD-10 3. American Society of Anesthesiologists (ASA) grade 2 4. Provides written informed consent for participation in the study.
Exclusion criteria
Exclusion criteria: 1. Presence of significant psychiatric co-morbidities (Schizophrenia, Bipolar disorder, and obsessive-compulsive disorder). 2. Presence of significant substance use disorder (Alcohol, cannabis, opioids) other than Nicotine and caffeine. 3. Presence of organic brain conditions (Dementia, Parkinsonism, Epilepsy, brain malignancy, space-occupying lesion (SOL), Increased Intracranial Pressure, significant brain injury in the past, significant cardiovascular injuries (except lacunar infarct), 4. Mental retardation, inability to provide an informed written consent. 5. Lactation and pregnancy. 6. Medical co-morbidities: Asthma, use of beta blockers, digitalis, calcium channel blockers, congestive cardiac failure, myocardial infarction (less than 6 months). 7. A family history of reaction with the study drug is known. 8. History of any reaction or serious adverse event with the study drug. 9. Pheochromocytoma 10. HR less than 50 bpm or presence of cardiac conduction or rhythm abnormality such as sick sinus syndrome, pre-operative hypotension (SBP less than 90mmHg) 11. If ketamine is used during ECT for any reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference in HAMD 21 and C SSRS scores in dexmedetomidine and non dexmedetomidine groupTimepoint: 1)Baseline: Just Before the delivery of first session (Day 0) 2)After every 7 days that is after 3 ECT sessions . 3) After completion of ECT. ( Average ECT sessions will be 6-8 and will be decided by treating physician ) | — |
Secondary
| Measure | Time frame |
|---|---|
| The difference in HAM A score and MoCA scores, and post ECT complication in dexmedetomidine and non dexmedetomidine groupTimepoint: 1)Baseline: Just Before the delivery of first session (Day 0) 2)After every 7 days that is after 3 ECT sessions . 3) After completion of ECT. 4) MoCA and post ECT complication checklist to be applied after every ECT session. ( Average ECT sessions will be 6-8 and will be decided by treating physician ) | — |
Countries
India
Contacts
Public ContactDr Ajay Kumar
AIIMS Raipur
Outcome results
None listed