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A study on changes in a saliva protein before and after dental cleaning in people with and without early gum disease

Comparative evaluation of leucine rich alpha 2 glycoprotein(LRG) in saliva of periodontally healthy and stage 1 grade A periodontitis Subjects and its response to scaling and root planing A clinico biochemical in vivo study - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/05/087325
Enrollment
50
Registered
2025-05-21
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Scaling and Root planing: Stage I Grade A periodontitis to be evaluated 6 weeks after Scaling and Root Planing Control Intervention1: none: Systemically healthy patients with healthy pe

Sponsors

TPCT s Terna Dental College and Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Subjects between the age group of 18 to 60 years. Subjects who readily give informed consent for the study. Subjects Having Pocket probing depth between 3-4mm, clinical attachment level 1-2 mm

Exclusion criteria

Exclusion criteria: Patients with any systemic disorders Patients with a history of smoking Pregnant and lactating females. Patients who have received any periodontal treatment in the previous 3 months Subjects who have received antibiotics, anti-inflammatory drugs, or any other drugs with past 3 months

Design outcomes

Primary

MeasureTime frame
1)To determine the levels of LRG in the Saliva of periodontally healthy subjects 2)To determine the levels of LRG in the Saliva of stage 1 grade A periodontitis subjects. 3)To compare levels of LRG in the Saliva of periodontally healthy and stage 1 grade A periodontitis subjects. 4)To evaluate the levels of leucine-rich alpha-2 glycoprotein (LRG) in stage 1 grade A periodontitis subjects after scaling and root planing. 5)To compare the level of leucine-rich alpha-2 glycoprotein (LRG) in saliva before and after scaling and root planning in stage 1 grade A periodontitis subjects Timepoint: At baseline and 6 Weeks After Scaling and Root planing—

Secondary

MeasureTime frame
To correlate clinical parameters like Plaque Index (PI),Gingival Index (GI),Probing Depth (PD),Clinical Attachment level (CAL), Bleeding on Probing(BOP), with Salivary levels of leucine-rich alpha-2 glycoprotein (LRG) in healthy and stage 1 grade A periodontitis subjects Timepoint: At baseline and 6 Weeks After Scaling and Root planing—

Countries

India

Contacts

Public ContactPrathamesh Kadam

T.P.C.Ts Terna Dental College And Hospital

rohitshah17@gmail.com9699860609

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026