A study to assess the analgesic efficacy of regional block for analgesia with three different doses of local anesthesia

A randomized comparative clinical trial of the analgesic efficacy of adductor canal block using 0.2% ropivacaine, 0.5% and 0.75% ropivacaine for postoperative management in total knee replacement - No

Status

Recruiting

Phases

Phase 3Phase 4

Study type

Observational

Source

CTRI

Registry ID

CTRI/2025/05/087318

Enrollment

120

Registered

2025-05-21

Start date

Unknown

Completion date

Unknown

Last updated

2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M96-M96- Intraoperative and postprocedural complications and disorders of musculoskeletal system, not elsewhere classified

Interventions

Intervention1: Adductor canal block using 0.5% ropivacaine: Ultrasound-guided adductor canal block will be given using 20 ml of 0.5% ropivacaine after surgery Control Intervention1: Adductor canal blo

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients above 18 years or older 2. Patients scheduled for elective unilateral total knee arthroplasty 3. Patients who are medically fit for regional anesthesia 4. Patients who have given informed consent to participate in the study.

Exclusion criteria

Exclusion criteria: 1. Patients with known allergies to local anesthetics used in the study 2. Patients with contraindications to regional anesthesia, such as infection at the site of injection, coagulopathy, or severe peripheral neuropathy 3. Patients with pre-existing neurological deficits in the lower extremities 4. Patients who are pregnant or breastfeeding 5. Patients who are unable to understand the study procedures or cooperate due to cognitive impairment or language barriers 6. Patients who refused to give consent.

Design outcomes

Primary

Measure	Time frame
To compare the quadriceps muscle strength between the two groups.Timepoint: checked at 1,2,4,8,12 and 24 hour	—

Secondary

Measure	Time frame
1.Comparing the NRS at various time points 2. Assessing the opioid requirement post-surgery for each block 3.Time to first analgesia (TTFA). 4.Comparing the time to ambulation post-surgery. Timepoint: 1. NRS will be checked at 1,2,4,8,12 and 24 hours 2. Total opioid dose in 24 hours 3. time to first opioid requirement in 24 hours postoperative period 4. Time to first ambulation in postoperative period	—

Measure

Time frame

1.Comparing the NRS at various time points 2. Assessing the opioid requirement post-surgery for each block 3.Time to first analgesia (TTFA). 4.Comparing the time to ambulation post-surgery. Timepoint: 1. NRS will be checked at 1,2,4,8,12 and 24 hours 2. Total opioid dose in 24 hours 3. time to first opioid requirement in 24 hours postoperative period 4. Time to first ambulation in postoperative period

—

Countries

India

Contacts

Public ContactDr Sandeep Diwan

Institute of Orthopedics and Rehabiliation, 16 Shivajinagar, Pune 411005 Pune MAHARASHTRA

sdiwan1965@gmx.com8279806434

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026