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Comparative antimicrobial efficacy of Triple Antibiotic Paste, 2% Chlorhexidine gel and Bromelain paste against Enterococcus faecalis in mandibular premolars - A Randomized clinical trial

Comparative evaluation of the Efficacy of Triple Antibiotic Paste, 2% Chlorhexidine gel and Bromelain paste as Intracanal Medicament against Enterococcus faecalis in carious permanent mandibular premolars of patients aged 18 to 40 years - A Randomized controlled clinical trial. - NIL

Status
Active, not recruiting
Phases
Phase 3Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/05/087311
Enrollment
24
Registered
2025-05-21
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: 2% CHX gel: CHX is widely used in endodontics due to its antimicrobial activity. It is used as both irrigant and intracanal medicament. here it is used as intracanal medicament for seve

Sponsors

SHRUNKHAL DILIP BHUPAL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients having age between 18 and 40 years irrespective of any gender. 2) Systemically healthy and co-operative patients will be selected. 3) Mandibular permanent premolars having deep caries approaching pulp radiographically. These teeth were diagnosed clinically as having necrotic or infected pulp and indicated for root canal treatment. 4) Mandibular premolars that exhibited carious involvement but had no prior history of restorations.

Exclusion criteria

Exclusion criteria: 1) Patients having any developmental anomalies of teeth. 2) Tooth having presence of a swelling or a sinus tract adjacent to the involved tooth, tenderness on percussion, pathologic tooth mobility, excessive hemorrhage from exposure site indicating progressive inflammation. 3) Tooth with internal resorption as well external resorption as seen on radiograph. 4) Cases requiring retreatment. 5) Individuals on antibiotic therapy within the three months leading up to the study; teeth. 6) Teeth with calcified canals, immature apex, periapical lesions.

Design outcomes

Primary

MeasureTime frame
Reduction in CFU count post medication S2 from S1 in each group was statistically significant. Percentage reduction in CFU count was highest in Bromlein group followed by TAP and 2% CHX group.Timepoint: At baseline and after seven days

Secondary

MeasureTime frame
NILTimepoint: NIL

Countries

India

Contacts

Public ContactSHRUNKHAL DILIP BHUPAL
surbhi17den@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026