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Combination therapy by use of patients own blood product after washing of the jaw joint space to evaluate effect in reducing pain & improving function in jaw joint disorders

Combination therapy of intra articular injection of pure platelet rich plasma after arthrocentesis to evaluate synergistic effect in reducing pain and improving function in TMJ disorders - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/05/087249
Enrollment
15
Registered
2025-05-21
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K088- Other specified disorders of teethand supporting structures

Interventions

Intervention1: Pure platelet rich plasma: Pure platelet rich plasma will be made from patients autologous blood only one time for a day during the washing of joint. It stimulates chondrocyte anabolism

Sponsors

AASTHA DAVE
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All healthy patients aged 18-45 years who will visit the department of oral and maxillofacial surgery, AMC dental college and hospital, Ahmedabad will be included in the study irrespective of sex, caste, religion or socio-economic status and all healthy patients after orthodontic and prosthodontics evaluation. ASA class 1 Patients with chief complaint of altered mouth opening, pathological joint noise, deviation on mouth opening, chronic tenderness on palpation or not responding to conservative management will be included in the study. Patients coming under (group II) disc displacement disorders and (group III) other TMJ disorders such as osteoarthritis and arthrosis of Research Diagnostic Criteria (RDC) will be included. Mild to moderate disc displacement seen on MRI Patients who are willing to give informed consent for the procedure. Patients who will agree to adhere to the study protocols

Exclusion criteria

Exclusion criteria: Infections/ pathological conditions at the planned surgical site. Patients on long-term NSAIDs will be excluded to avoid impaired platelets for pure PRP fabrication Patients with coexisting conditions such as rheumatic disease, autoimmune or neurological disorders. Patients with coagulation or bleeding problems. Group I (muscle pain) of Research Diagnostic Criteria. Medically compromised patient. Patient with history of radiotherapy to the head and neck region or treatment with bisphosphonates Patients with inability to adhere to the schedule or not willing to give written consent.

Design outcomes

Primary

MeasureTime frame
It shall have effect in pain reduction, improving stiffness, mouth opening, clicking and deviation of jaw from 3 weeks to 12 weeks after the procedure Timepoint: 3 weeks, 6 weeks and 12 weeks

Secondary

MeasureTime frame
nilTimepoint: nil

Countries

India

Contacts

Public ContactAASTHA DAVE

AMC dental college & hospital

daveaastha09@gmail.com9033601408

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026