Health Condition 1: N185- Chronic kidney disease, stage 5
Conditions
Interventions
Intervention1: Group P: Subjects will receive propofol for maintenance anaesthesia with closed loop anaesthetic delivery system, targeting BIS of 50.
Duration of intervention: 2 hours
Control Interv
Sponsors
Post Graduate Institute of Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age group 18 to 60 years 2. Both male and female gender 3. Informed consent obtained from patients
Exclusion criteria
Exclusion criteria: 1. Pre-existing cognitive impairment/dementia 2. Severe cardiac dysfunction / hepatic dysfunction 3. Limited language comprehension 4. Concurrent use of antiepileptics or antidepressant medications 5. Allergies to any of the anaesthesia components
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of post-operative delirium during the first 24 hours post-extubation.Timepoint: Every 2 hourly until first 24 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of post-operative delirium(POD) at any time point during ICU stay Incidence of early postoperative cognitive dysfunction (POCD) Any Associated complications(Delayed graft function,Wound infection, reexploration etc) Numerical rating scale for pain during first 3 days Duration of ICU stay and Hospital stay Timepoint: Incidence of POD at any time point in ICU stay assessed twice daily until discharge from ICU Incidence of early POCD (assessed on POD 1,3,5 and at Day 7/at discharge from ICU) | — |
Countries
India
Contacts
Public ContactDr Naveen Naik B
Post Graduate Institute of Medical Education and Research
Outcome results
None listed