How Root Canal Treatment Affects Heart Health and Inflammation in People with Infected Front Teeth

Effect of root canal treatment on hs-CRP levels and non-invasive cardiovascular risk marker in systemically healthy individuals with apical periodontitis of anterior teeth a prospective clinical study - Nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/05/087188

Enrollment

Registered

2025-05-20

Start date

Unknown

Completion date

Unknown

Last updated

2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: High sensitivity C-Reactive Protein and Carotid Artery Intima Media Thickness Levels before root canal treatment: High sensitivity C-Reactive Protein and Carotid Artery Intima Media Thi

Eligibility

Inclusion criteria

Inclusion criteria: 1 Individuals with primary Apical Periodontitis of single rooted anterior teeth associated with Apical Lesions of Endodontic Origin, and the absence of acute or chronic systemic diseases. 2 Individuals with a single tooth diagnosed with apical periodontitis with no response to pulp sensibility tests and with a Periapical Index score greater than or equal to 3.

Exclusion criteria

Exclusion criteria: 1 Diagnosed non-communicable systemic diseases. 2 Obesity (body mass index (BMI) greater than or equal to 30 kg/m2) 3 Pregnancy 4 Acute infection 5 Smokers 6 Patients with previously endodontically treated teeth with periapical radiolucencies

Design outcomes

Primary

Measure	Time frame
Decrease in hs-CRP and CIMT levels after root canal treatmentTimepoint: Decrease in hs-CRP and CIMT levels after 3 months and 6 months of root canal treatment	—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactAnnam Sai Sri Rishi

Kamineni Institute of Dental Sciences

drsjayapradareddy@gmail.com09381240290

Outcome results