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A study to compare how well low doses of ketamine or lignocaine work to prevent pain when propofol is injected into a vein. The study is done in a fair and unbiased way, where neither the patients nor the researchers know who gets which medicine

A Randomised Double-Blind Controlled Study to Evaluate the Efficacy of Low-Dose Intravenous Ketamine Versus Intravenous Lignocaine for Prevention of Pain Associated With Intravenous Injection of Propofol - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/05/087154
Enrollment
100
Registered
2025-05-20
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: GROUP A - inj. Ketamine: inj. ketamine 0.2 mg/kg iv Control Intervention1: GROUP B- inj. Lidocaine: inj. lidocaine0.5 mg/kg iv Control Intervention2: GROUP B- Inj. Lidocaine: Inj. Lidoc

Sponsors

JLN medical college
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA grade I, II 2. Elective surgical procedure under general anesthesia 3. Patients willing to give written informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients having known allergy to propofol and anesthetic agents will be used in study. 2. Hemodynamically unstable patient, Pregnant women, morbidly obese, history of neurological & psychological disorders, with acute or chronic pain syndromes, patients with difficulty in communication and patients who had received any sedatives and analgesic medications before surgery 3.Patients who are unwilling to participate in the study.

Design outcomes

Primary

MeasureTime frame
1. Difference in number of cases who experience pain on injection in both groups. Timepoint: To assess and compare prevention of pain associated with iv injection of propofol in both groups at different time intervals.—

Secondary

MeasureTime frame
1. Difference in hemodynamic variations from base line at different time interval in both groups. 2. Difference in number of cases who has side effect in both groups.Timepoint: Baseline—

Countries

India

Contacts

Public ContactDr Veena Patodi

Jawahar lal nehru medical college

veenapatodi@gmail.com9414008276

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026