The effect of intranasal dexmedetomidine and lignocaine spray on the laryngoscopy response during intubation.

Comparison between intranasal dexmedetomidine and oropharyngeal lignocaine spray on attenuation of stress response during laryngoscopy for tracheal intubation in patients undergoing elective surgeries - A triple blinded randomized controlled trial. - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/05/087140

Enrollment

204

Registered

2025-05-20

Start date

Unknown

Completion date

Unknown

Last updated

2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Dexmedetomidine: 1 mcg per kg intranasal Dexmedetomidine using mucosal atomization device 30 minutes prior to induction of anaesthesia. 1microgram per kilogram dose of dexmedetomidine i

Eligibility

Inclusion criteria

Inclusion criteria: Adults of age 18 and 60 years of ASA I and II undergoing elective surgery under general anaesthesia with oral endotracheal tube intubation

Exclusion criteria

Exclusion criteria: Patient refusal Allergy to either dexmedetomidine or lignocaine ASA III and IV Anticipated difficult airway Severe upper respiratory tract infection Known cardiac disease or liver disease BMI greater than 30kg per m2 Pregnant women

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of intranasal dexmedetomidine and lignocaine spray on the laryngoscopy response in patients undergoing elective surgeriesTimepoint: baseline , 2 minute, 5 minutes, 10 minutes post tracheal intubation. Heart rate and Blood pressure will be measured	—

Secondary

Measure	Time frame
Incidence of sore throat in patients post endotracheal intubationTimepoint: more than 6 hours to less than 10 hours post surgery	—

Countries

India

Contacts

Public ContactRaichel Kurian

Christian Medical College Vellore

sajanpg@cmcvellore.ac.in0416 2282105

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026