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Improving Gum Infection Treatment using a New combination of blood product and antibiotic drug

Clinical and microbiological analysis of biofunctionalized metronidazole as an adjunctive local drug delivery system in non-surgical treatment of periodontal abscess - NIL

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/05/087134
Enrollment
33
Registered
2025-05-20
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K055- Other periodontal diseases

Interventions

Intervention1: Metronidazole enriched injectable Platelet rich fibrin: Metronidazole enriched Platelet rich fibrin group will receive scaling followed by drainage of the periodontal abscess followed b

Sponsors

Dr T Jaya Sree
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Isolated periodontal abscesses 2. Clinically detectable ovoid swelling in the buccal or lingual gingiva 3. Periodontal pocket depth greater than or equal to 4mm 4. Alveolar bone loss on IOPA 5. systemically healthy subjects (ASA-I) in the age range of 20 to 60 years

Exclusion criteria

Exclusion criteria: 1. Abscess extending to the adjacent teeth 2. Use of medications affecting periodontal status 3. Presence of uncontrolled systemic disease 4. History of Antibiotic use within 1 month 5. History of Anti-inflammatory drugs or antiplatelet drugs 6. Patients on antiplatelet or anticoagulant drugs 7. Pregnant or lactating women 8. Smokers

Design outcomes

Primary

MeasureTime frame
1. Probing pocket depth (UNC-15 probe) 2. Clinical attachment level (UNC-15 probe) 3. Gingival bleeding index (Amino and Bay) 4. Swelling reduction (linear measurements) 5. Quantitative analysis of (Porphyromonas gingivalis), (Tannerella frosythia), (Treponema denticola), (Aggregatibacter actinomycetecomitans) will assessed by multiplex PCR Timepoint: Baseline, one week, one month, three months

Secondary

MeasureTime frame
1. Pain relief 2. Patient satisfaction Timepoint: baseline, 1 week

Countries

India

Contacts

Public ContactDr N V S Sruthima G

Vishnu Dental College

sruthima@gmail.com9492293808

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026