Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Group A will be given oral methotrexate and folic acid: Oral methotrexate 0.3mg/kg once a week per oral with Folic acid (5mg) supplementation to be given 5 day/week for 13 weeks
Control
Sponsors
Dr RPGMC Tanda
Eligibility
Inclusion criteria
Inclusion criteria: 1 Patients having moderate to severe chronic plaque psoriasis with more than 3 percent of body surface area involved by psoriasis with or without psoriatic arthritis. 2. Patients having moderate to severe chronic plaque psoriasis (defined by a score of at least 3 on the Psoriasis Area and Severity Index (PASI). 3. Patients of psoriasis not on any form of systemic antipsoriatic treatment for at least 4 weeks and or topical treatment for at least 2 weeks prior to the initiation of therapy.
Exclusion criteria
Exclusion criteria: 1. Patients less than 18 years of age. 2. Pregnant and or lactating females. 3. Patients noncompliant with an effective regimen of contraception 4. Patients having hepatic or renal impairment, deranged lipid profile. Hematologic impairment, any acute infection requiring antimicrobial therapy. Uncontrolled hypertension or diabetes mellitus, with BMI more than 30, or known psychiatric illness. 5. Patients having a history of cancer, including skin cancer or hematologic, cerebral or pulmonary neoplasia. 6. Patients who are alcoholic or have a long history of alcohol intake.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Side effects related to treatmentTimepoint: After each visit | — |
Primary
| Measure | Time frame |
|---|---|
| Grade of improvement by reduction of PASI scoreTimepoint: It will be determined initially at baseline, end of first week, then every two weekly for next four weeks and then every four weekly during the next two months thereafter. | — |
Countries
India
Contacts
Public ContactDr Akanksha
Department of DVL, Dr RPGMC Tanda
Outcome results
None listed