Study comparing the effect of Spinal Morphine and Spinal Buprenorphine for fast tracking Cardiac Anaesthesia

A Comparative Study of Intrathecal Morphine vs Intrathecal Buprenorphine for Fast Track Cardiac Anaesthesia: A Randomised Control Trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/05/087101

Enrollment

Registered

2025-05-20

Start date

Unknown

Completion date

Unknown

Last updated

2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I52- Other heart disorders in diseasesclassified elsewhere

Interventions

Intervention1: Intrathecal Buprenorphine: Upon free return of clear cerebrospinal fluid,solution of buprenorphine (1 mcg/kg buprenorphine diluted in NS to 10 mcg/ml upto a maximum of 50 mcg) will be i

Eligibility

Inclusion criteria

Inclusion criteria: Cardiac surgery patients above 18 years of age posted for elective cardiac surgery via midline sternotomy suitable for fast track cardiac anaesthesia

Exclusion criteria

Exclusion criteria: 1. Patients who refuse to participate in the study 2. Emergency surgery 3. Redo surgery 4. Patients with allergy or intolerance to study drugs 5. Patients with contraindications to spinal block 6. Patients with EUROSCORE more than 5 7. Patients with ASA class more than III 8. Patients with preoperative LV dysfunction (LVEF less than 40%) 9. Preoperative cardiac support (IV inotropes or vasopressors, IABP) 10. Patients on mechanical ventilation preoperatively 11. Patients with preoperative diabetes, liver or kidney dysfunction, pulmonary dysfunction, coagulopathy, sleep apnoea or OSA 12. Morbid obesity (BMI more than 35 kg/m2) 13. Addiction to study drugs 14. Any other condition as per anaesthetist s discretion that precludes fast track cardiac anaesthesia (CPB time more than 180 minutes , surgery duration exceeding 6 hours, incomplete surgical correction, massive blood transfusion, core body temperature less than 35oC, time to extubation more than 6 hours)

Design outcomes

Primary

Measure	Time frame
To compare the time taken to extubation after cardiac surgery Timepoint: Baseline	—

Secondary

Measure	Time frame
To compare postoperative verbal analogue scale at rest and on coughing in the 1st 24 hours.Timepoint: After extubation, 2hrs, 6hrs, 12 hrs;To compare number of rescue analgesicsTimepoint: ;To compare postoperative inspiratory capacity after extubationTimepoint: After extubation, 2hrs, 6hrs, 12 hrs	—

Countries

India

Contacts

Public ContactDr Suruchi Hasija

All India Institute of Medical Sciences, New Delhi

suruchi_hasija@hotmail.com9818515020

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026